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Light Switch for Gene Expression
Saturday, 19 May 2012 04:08

Just about everything about a person is described by their DNA. How we look, how tall we are or will be, whether we can get certain diseases, and even our intelligence (to a degree) is written in our genes. Also genes can affect diseases such as cancer, which is the uncontrolled growth of cells with mutated genetic information. Researchers at have developed a way to selectively control if a gene is expressed or not with UV light.

Of course there is more than just light involved. The UV light just acts as a switch for triplex-forming oligonucleotides (TFOs) which are commonly used for controlling gene expression. These molecules will attach to DNA and block transcription, and the researchers wanted a better way to control them. This was accomplished by attaching them to a light-activated 'cage,' so that only when the UV light hits the cage is the TFO able to attach to the DNA. The researchers also created the converse system, which only allows the TFO to attach to the DNA when UV light is not present.

This level of control should allow other researchers to very selectively turn on and off specific genes whenever they wish to. Such an ability will allow researchers to better understand what certain genes do, which may then lead to improved treatments for many diseases.

 
Hardware Roundup: Thursday Edition
Saturday, 19 May 2012 04:08

We have quite a busy day today with lots of reviews for you to read. We'll begin with another look at the mouse and keyboard combination. If you're into silent computing, how about a computer with no moving parts (unless you count the optical drive)? The Chillblast Fusion Vacuum is passively cooled and is equipped with a solid state drive. You can't get much quieter than that. We have an article with details on the Kepler GK110 GPU from NVIDIA along with a pair of reviews covering the video card. As you can see, we have plenty more in store for you, so kick back and dig in using the links below.

Cooling
@ Bjorn3D
@ Frostytech.

Input Devices
@ [H]ardOCP

Memory
@ Benchmark Reviews

Mobile
@ LanOC Reviews

Monitors/TVs
@ ThinkComputers

Motherboards
@ LanOC Reviews

Prebuilts
@ XSReviews

Video
@ PC Perspective
@ Neoseeker
@ LanOC Reviews

 
Blizzard Apologizes for Diablo III Server Issues - Postpones Real Money Auction House
Saturday, 19 May 2012 04:08

The server issues that have been troubling Diablo III since launch are , which has prompted on the subject. Blizzard posted the apology on the Battle.net forums, where it says launch preparations "did not go far enough." The studio has been optimizing and fine tuning the servers since May 15th, and everything should be running smoothly now. There will be some maintenance periods to ensure all regions can connect without issue and Blizzard will continue to monitor server activity. Blizzard wants to make sure everything is running properly and there are no more widespread server problems, so it will be delaying the launch of the real money auction house beyond the expected May 22nd start date. The studio will provide a future update when it is ready to go ahead with the real money auction house. Blizzard is sorry the server issues prevented some people from enjoying Diablo III, and thanks everyone for their patience.

 
Many Facebook Users Refuse to Click Ads
Saturday, 19 May 2012 04:08

Facebook received some less than ideal news earlier this week when it was revealed that General Motors would be pulling $10 million worth of ads from Facebook from a total a $40 million. A survey conducted by marketing agency Greenlight found that would never click ads on Facebook. Only 3% of those polled said they regularly clicked ads on Facebook. This comes before the IPO of Facebook which happens tomorrow and is expected to value the company at more than $100 billion. The company is in the unique position that it can use the information you provide to produce targeted ads. I have never intentionally clicked a Facebook ad, but the "Find girls in your area that like Slayer" ad was very tempting.

 
Corsair Upgrades Gamer Series Power Supplies
Saturday, 19 May 2012 04:08

Corsair has announced that its of power supplies has received upgrades to boost power and cooling efficiency. The boost in energy efficiency grants the Gamer Series 80 PLUS® Bronze certification, which means that the Gamer Series operates at up to 85% efficiency under normal loads. The PSU will also be able to maintain fanless cooling operation at low load levels, providing the user with a much quieter system when it isn't being taxed. The new Gamer Series power supplies will be available at 600W, 700W, and 800W. All Gamer Series power supplies come with a three year warranty.

 
First Details of Unreal Engine 4 Revealed
Saturday, 19 May 2012 04:08

Back in March, Epic Games was showing off Unreal Engine 4 behind closed doors and an NDA. Today the studio is opening up a little bit more about the new engine and that we can expect a lot more information at E3 next month. The team over at Wired conducted an interview with Epic Games founder Tim Sweeney about , and I have to say, it is well worth the read. For starters, Epic has assembled a two and a half minute demo reel that shows off everything UE4 can do for developers. The demo reel has a demon knight in his volcano fortress with a ton of effects (lens flare, bokeh distortion, dynamic lighting, lava flow, environmental destruction, lava, and more) going around, and according to Wired, "it's breathtakingly photo-realistic." While the clip is not yet available, we do have a plethora of screenshots for you to peruse and gawk over. I imagine the clip will be shown during E3, so it looks like we have a few weeks left before seeing it.

As for Unreal Engine 4, Epic Games says it features tools that will allow developers to cut production times in half. This will mean more games can be produced each year if Epic's claims are accurate. The screenshots from the demo reel look amazing, but then that begs the question of just what kind of hardware will be necessary to get all games looking this good. I suppose we will find out in a few weeks.

 
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